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apalutamide will reduce the level or influence of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. Coadministration of apalutamide, a powerful CYP3A4 inducer, with medication which can be CYP3A4 substrates may result in decrease exposure to those remedies.If you miss out on a dose, take it